Sriram was born as Srikanth into a Tamil speaking family in Tirupati. He married Vandana in November 2007, who had completed her MBA in Australia. The couple has two children: a son and a daughter.
2002-2009: Debut success
Srikanth debuted in Sasi's romantic film Roja Kootam (2002), which was a commercial success. Srikanth then featured in another successful venture April Madhathil (2002) alongside Sneha followed by Manasellam (2003). He won the Tamil Nadu State Film Award Special Prize for his role in Parthiban Kanavu (2003), directed by Karu Pazhaniappan. Srikanth's straight Telugu film is 2003's Okariki Okaru. Srikanth released his film under the name Sriram, to avoid confusion with another Tollywood actor, Meka Srikanth. His first release of 2004 was Varnajalam, followed by Bose, in which he was paired with Sneha for the second time after April Maadhathil. Kana Kandaen (2005) directed by K. V. Anand, with the Malayalam actor Prithviraj in his first Tamil role. Srikanth and Prithviraj gave a good performance also. The film was followed by Oru Naal Oru Kanavu (2005) and Bambara Kannaley (2005). In 2006, he acted in the film Mercury Pookkal, and Uyir. Behindwoods wrote: "Sri has come up with an excellent performance of a man lost in this juggernaut of emotions." TSV Hari at Rediff.com responded negatively to Kizhakku Kadalkarai Salai, noting a thin script and "meaningless songs". This was the third film and last collaboration between the director S. S. Stanley and Srikanth after April Maadhathil and Mercury Pookkal. His next film was Aadavari Matalaku Arthale Verule, a Telugu film directed by Tamil director Selvaraghavan. Srikanth play the second lead role after Telugu actor Venkatesh Daggubati. This was followed by Vallamai Tharayo (2008), Poo (2008) and Indira Vizha (2009).
2010-2014: Setbacks and success
In 2010, Srikanth released Rasikkum Seemane, Police Police and Drohi. Srikanth co-starring with the new Tamil actor Vishnu Vishal in this film. Mandhira Punnagai was last released in guest appearance. In 2011, he began in Malayalam film Uppukandam Brothers: Back in Action, a Telugu film, Dhada and Sadhurangam. The film was completed in 2006 but the film remained unreleased for five years. The project was released on 7 October 2011. These three movies was a box office failure. In 2012, he was first seen in S. Shankar's comedy-drama Nanban, which featured him as part of an all-star cast including Vijay, Jiiva, Ileana D'Cruz and Sathyaraj. The movie is released to highly positive reviews. He also started in Telugu film Nippu (2011), a Malayalam film Hero (2012) and comedy film Paagan (2012). In 2013, he acted in Buddy and Kathai Thiraikathai Vasanam Iyakkam (2014) as guest appearance directed by R. Parthiepan.
He acted in Om Shanthi Om (2015), Sowkarpettai (2016), the first horror movie and comedy film Nambiyaar (2016). In 2017, Srikanth appeared in the Telugu action thriller Lie. Critic Ch Sowmya Sruthi said the film, "offers some out-of-the-box antics for people who love experimental cinema packed with thrill. The nail-biting experience that the second-half offers goes south towards the end."